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We publish essentially the most up-to-date information for a medication based on its licence history. The total physique clearance of sildenafil is 41 L/h with a resultant terminal section half- life of 3-5 h. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately four h. There was no effect on sperm motility or morphology after single 100 mg oral doses of sildenafil in healthy volunteers (see part 4.6).
- Single oral doses of sildenafil as a lot as 100 mg in wholesome volunteers produced no clinically related effects on electrocardiogram (ECG).
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